Poisonings by Cardiovascular Drugs in Yekaterinburg, Russia
Authors
Abstract:
Background: The pattern of poisoning in Russia may be different from other countries. The study objective was to describe the pattern of poisoning with cardiovascular drugs in a major industrial city in Russia, Yekaterinburg. Methods: This study was part of a larger prospective multi-center study including all acute poisonings in patients older than 15 years of age in the city of Yekaterinburg, during March 2009 to March 2010. Patients with main diagnosis of acute poisoning by cardiovascular drugs and two other commonly used drugs affecting cardiac system were included. Results: Cardiovascular drugs were the main poisoning agent in 269 cases of 3,112 acute poisonings (8.6%) during the study period. Median age of the patients was 36 (range: 16-88) years and 108 patients (40%) were men. Over 85% of patients required hospital admission and ICU care was needed for 45.7% of patients. Men significantly outnumbered women in veratrine poisoning (P < 0.001) while women significantly outnumbered men in clonidine (P < 0.001), drotaverine (P < 0.001), CCB (P < 0.001) and beta blocker (P = 0.012) poisoning. The most frequent complications were hypotension (83 patients; 30.8%), cardiac arrhythmias (22 patients; 8.2%) and QT prolongation (5 patients; 1.9%). The main agents significantly associated with hypotension were the phenylalkylamine and benzothiazepine subclasses of CCBs (verapamil/diltiazem), veratrine, beta blockers, nitrates, ACE inhibitors, clonidine, and adelphan. In total, mortality rate was 4.1%. The highest rate of death was recorded for poisoning with verapamil/diltiazem (20%) followed by dihydropyridine subclass of CCBs (9.1%). Conclusion: The most common drugs causing hypotension and cardiac arrhythmias were clonidine, CCBs, drotaverine and the veterinary drug “veratrine”. Drotaverine, clonidine and CCBs were the most common drugs causing death. Poisonings with these agents are rare in other countries. Measures to reduce the availability of drotaverine and veratrine should be taken in Russia.
similar resources
A Clinico-Epidemiological Study on Poisonings due to Cardiovascular Drugs in Ahvaz, Iran
Background: Overdoses with cardiovascular drugs are related with significant morbidity and mortality. Beta-adrenergic blockers, calcium-channel blockers (CCBs), thiazide, digoxin and angiotensin converting enzyme (ACE) inhibitors represent five of the most important classes of cardiovascular drugs. Overdoses with cardiovascular drugs are typically caused by exploratory ingestion by children or ...
full textWinter mortality and cold stress in Yekaterinburg, Russia: interview survey.
OBJECTIVES To evaluate how mortality and protective measures against exposure to cold change as temperatures fall between October and March in a region of Russia with a mean winter temperature below -6 degrees C. DESIGN Interview to assess factors associated with cold stress both indoors and outdoors, to measure temperatures in living room, and to survey unheated rooms. SETTING Sverdlovsk O...
full textFatal Alcohol Poisonings and Traffic Accidents in Russia
Correspondence to: Grodno State Medical University, 80 Gorky Street, Grodno 230009, Belarus tel.: + 375 0152 70 18 84, fax: +375 0152 43 53 41, e-mail: [email protected] [email protected] Copyright © 2015 KBCSM, Zagreb e-mail: [email protected] • www.http//hrcak.srce.hr/acoholism Abstract – Russia has one of the world’s highest road traffic fatality rates. There is common belie...
full textRhabdomyolysis Syndrome in Alcohol, Psychotropic Drugs, and Illicit Substance Poisonings
Background: Rhabdomyolysis is one of the major complications of poisoning caused by alcohol, narcotics, and psychotropic substances acute toxicity, which might lead to acute renal failure and even death. This study aimed to evaluate clinical and laboratory findings of rhabdomyolysis syndrome in poisoning patients who were admitted to poisoning ward of Farshchian Hospital of Hamadan, Iran. Meth...
full textLong-term observation of amphibian populations inhabiting urban and forested areas in Yekaterinburg, Russia
This article presents data derived from a 36 year-long uninterrupted observational study of amphibian populations living in the city and vicinity of Yekaterinburg, Russia. This area is inhabited by six amphibian species. Based on a degree of anthropogenic transformation, the urban territory is divided into five highly mosaic zones characterized by vegetation, temperature, and a distinctive wate...
full textMy Resources
Journal title
volume 5 issue 1
pages 3- 10
publication date 2016-03-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023